Diaper Rash: BOB

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Help with Diaper Rash

I have some questions about diaper rash. I'm a first time mother with twins, and it seems like we're always getting diaper rash. Am I just supposed to expect it constantly or are there ways to avoid it? I feel like as soon as we get it cleared up, it's back the next day. Is there a preventitive cream I'm supposed to use at all changes? And once I put cream on it how soon should I see improvements before I call the doctor about it? I use desitin and sometimes burts bees, but do you recommend other types? thanks!