B.B.
I have definitely been in her shoes, and went through a pretty bad bout of depression because of it. I grew up in a German/Irish/Catholic town where it was assumed that getting pregnant was as easy as breathing, and for everyone I knew, it was - except me. There was pretty much nothing anyone could say to me to make it better - because they were all able to get pregnant without "help". It still bothers me that there are people who can get pregnant by just thinking about it or just "looking at a baby", and I had to go through having 2 doctors and 4 nurses in the room with me transferring embryos for me to be able to conceive.
And sex does become a chore because it's a planned chore instead of a spontaneously fun/enjoyable activity. Plus nobody ever talks about NOT being able to get pregnant, so when you do experience that, it's like you're an isolated instance and you don't know what to do. You're scared to go to the doctor for fear of "what they'll find" and are even more scared to talk to somebody (other doctor) about it for fear of what they'll tell you.
Keep in mind that there are other aspects that can affect getting pregnant...hormone imbalance, polyps, PCOS (www.pcosupport.org), autoimmune antibodies, endometriosis, blocked tube(s), etc. And with many of these things, there are things the doctor can do to counter those effects. I have autoimmune antibodies that make my blood clot too fast. If by some miracle, an egg went down the one tube I have that's open and tried to implant, the blood would clot around it and abort before it ever got going. There's nothing I did to bring this on - it's just the way my body works - and there was something that could be done about it too.
Anyway - what I can tell you is - I've been through the drama of going to the OB/GYN, we went through 6 cycles of clomid to no avail, and then went through 2 "assisted reproductive technology" cycles with a reproductive specialist and have 2 beautiful daughters.
Meanwhile, there's a book she should read by Dr. Alice Domar called "Conquering Infertility". I hate to read, but couldn't put that book down! One thing she could do before going to the dr.'s is to start charting her temperatures every morning before she lifts a finger to get out of bed, starting with the first day of her period (which is "cycle day 1). It's supposed to look like a "standard bell curve". (Mine didn't; mine looked like the Rocky Mountains, and I didn't realize that that meant something.)
I'd be happy to talk to or trade email's with your friend so she can know what to expect if/when she goes to the OB/GYN or on to a "specialist", and even let her know who my doctors were.