I wonder if you should try a selfish kind of high road. It's selfish because it's grounded more on mental and emotional self-preservation than on generosity toward the other guy.
I understand your situation because it has happened to me. I have to remind myself that I am not now and never have been the center of the universe... and there's really no law against people ignoring me! I'd try to shrug off the situation, get a humorous slant on it if I can, and turn instead to people who I know are my friends. My junior high days are long past, and I do NOT want to return to the angst of what other folks think or don't think of me.
Sometimes it happens that NOT being involved with a person turns out to be a blessing. People act in strange ways and we may NEVER know why. They may not know why themselves.
Maybe they have a problem you just don't know about, and maybe you shouldn't try to make their problem yours. If they want to act cold to you, can you just let it be THEIR problem? You already know you're a nice woman! Think about what these people are missing!
Perhaps one day one of your other friends might bring them up in conversation, and MAYBE you might be able to say, casually, "I wish I knew them better, but for some reason they don't seem to want to know me. Oh well...."