I'm a dental hygienist. My son is 22 months, now. Tooth care can be challenging with a toddler, but we just don't allow it to be a negotiable in our family! The way I do it with him is I let him brush his own teeth after breakfast and lunch. We go into the bathroom and brush our teeth together. Mostly, he just chews on the brush, but I show him how I move mine around on my teeth to get them clean. I also have him practice brushing his tongue (like I do). He thinks that's funny and gets into it a lot more than brushing his teeth! Then, at bedtime, I have him lie down on the bed while I brush and floss his teeth thoroughly. We used to have some royal battles over this, but I refused to give in--it was too important! When I'm working in his mouth, he is not allowed to have his hands in or near his mouth or touching the brush or floss. I allow him to swallow frequently, but in between, he is expected to keep his mouth open. I praise him profusely when he cooperates well, but when he doesn't, I firmly sqeeze the outside of his cheeks (with my thumb on one side and fingers on the other) to hold his mouth open. It's not comfortable and he hates it, so he quickly learned that it is much better if he just opens his mouth himself. I know that probably sounds harsh, but I make sure we always end on a positive note. And after I'm done (flossing or brushing) I let him have a turn, also. I've found that with little children it is much easier to have them lie on a bed--helps to keep them from moving around so much and give you a better view of what you're doing! It does make spitting difficult, but if your daughter is like my son, she doesn't really spit, anyway. That's why they make baby toothpaste without fluoride. Once you have brushing in a prone position mastered, then you can start working on doing it in the bathroom at the sink. Also, at this age it is only necessary to floss between teeth that actually touch eachother. If there are spaces between any of her teeth, don't worry about flossing there. And as long as you're getting one thorough brushing in each day (preferably before bedtime), you're doing well. Probably the other most important thing, right now, is to make sure that she isn't sipping on milk or juice throughout the day, or going to bed with milk or juice in her bottle. Restrict milk and juice to meal or snack times. Give her water at any other times.