D.B.
Can you add more information please? What have you already discussed with their doctor at their annual physicals (when certainly this issue must have come up)? What did the doctor say?
Are the other issues involved, such as family history, extreme weight issues (high or low), eating disorders, medications. excessive exercise, nutritional problems?
What other secondary sexual characteristics are present? (Pubic and underarm hair, breast development and so on.) Were/are they both later in developing these?
You're giving us nothing to go on.