I lived in Louisville and the surrounding area for about 13 years. Louisville is the largest city in KY and is home to tons of restaurants, theaters, universities, and other cultural attractions, so there would probably be a lot of opportunity for your husband's business.
I don't know how much land you want, but like anywhere, the farther out from the city, the more options you have for larger properties. I really like the east side of town, and still have many friends who live there. There are some great small towns outside of the Louisville (about 30 min drive) where you have even more land in Oldham county (La Grange, Goshen, etc). Oldham county used to be known for very good schools.
Another option is to go across the river to Southern Indiana, about a 10 minute ride from downtown Louisville. New Albany (lived there nearly 5 years), Jeffersonville, and Clarksville are the three of the main cities, but there are many smaller nearby towns and rural areas with lots of land.
Shelbyville, KY is a nice area, not too far from Louisville, so your husband could still be in proximity to the city.
Along the back way from Louisville to Lexington, you'll see a lot of horse country. It's beautiful, but many of these properties are quite expensive, as you'd imagine.
Kentucky gets lots of rain so everything is green and lush. You will still get snow and cold winters. Fall is a beautiful time. I miss the changing leaves as I live in the desert now. It can be very humid, but not as bad as FL.
There is so much history in KY. Each part of the state has its own beauty and stories to tell. Go to the websites for Louisville, Lexington, Frankfort, Shelbyville, Bardstown, Bowling Green, Danville to start with, and you'll begin to get a feel for what the state has to offer.
I wish you the best in your search! Send me a PM if you have any other questions I can help with.
J. F.