I have a 4 year old who just starting wetting the bed. He hasn't been in pull-ups for over a year, but we did recently move, had a baby, then 5 weeks later lost our baby and I quit as a pre-school teacher to stay at home with my boys so I pulled them out of school. SO we've gone through a ton of changes. Think if your family has gone through any major changes or even any suttle ones since all this began. Maybe she feels as though somethings changed and she's loosing control or needs her schedule changed now that she's getting older. Maybe her schedule needs to be different from her sisters, or younger siblings and she doesn't know how to express it. We now put a shower curtain liner down under the sheet so it doesn't mess up the mattress, and we do like you and wake our son to go in the middle of the night. But, withe the grace of God we've been able to re-adjust his schedule and make things more consistant. We've looked at the rules he has versus his 2 year old brother and what things he needs in order to feel in control of his world. H'e s 4 and she's 5 and even though they can speak emotions are still hard to decipher at that age, gosh let alone any age. Some grown-ups can't do that. Hehe. But, then also I had a boy in my 4 year old pre-school class who wet himself consistantly and he had a bladder control problem. He has to take medicine for it, so you have some options, but that's my opinion. Hope it helps. God Bless - KWalters