LMFAO.... ohhhhhhh I am dreading the day I do this and I know it will be coming soon enough! Anyhow, I doubt it would be irratating to the skin considering the child wears them in the first place :) The only thing I have to suggest is getting one of those tape lint rollers and rolling the clothes to get the shiny fibers off. I usually can find them in the laundry section or in the check-out line at Walmart.... probably the pet section also!
Also, if you are still worried, here is the phone number to Kimberly Clark Products/Pull-ups 1-888-525-8388. You can call them and ask their advice!
Good luck to you and GET SOME SLEEP! lol
Blessings!