First of all, HUGE HUGS to you! I'm so sorry you and your little one are going through this. It's very hard to see your baby in pain like that.
You have some good advice here. If Zantac and Prilosec aren't helping, I would switch to something else though. Zantac is an acid suppresser, Prilosec is an acid blocker. Your little one might need something like Reglan (a mom I know had good success with this one), which is a motility medicine (helps keep the food moving). Are you breastfeeding? It may be something you're eating. Anything acidy, spicy or fatty that you eat will trigger her reflux. Has her PedGI done a barium swallow x-ray to make sure it's reflux and not an allergy? (Although the crying certainly does point to reflux.) And the hoarse throat could very well be from the stomach acids irritating the lining of her esophagus.
Here's my story: My son was diagnosed with GERD at 3 days. Why only 3 days? Because most of my husband's family were diagnosed with GERD later in life (as babies, everyone said they were just colicky, ha!) and I developed it in my seventh month of pregnancy. So, when my son came out, we knew what symptoms to look for. At 3 weeks, we did the barium swallow and, just as expected, he spit everything up. We started with Prevacid first because that's the medication that works for my husband and his family. It took 2-4 weeks to kick in, but it helped with his pain and crying immensely! However, he was still spitting up and wasn't gaining weight well on my breastmilk. I tried limiting what I ate with an allergy elimination diet; no dice. Finally, both his Ped and the PedGI ruled it wasn't working and we had to switch to Similac Alimentum. It was an almost instant success. He kept food down except for 3-4 spitups per day and started gaining weight. We kept him on Prevacid until he was about 18 months old. At that point, he hadn't had an episode for a month and his PedGI said it was safe to take him off the medicine. At two, he's still smaller than his peers, but some of that is genetics. But he's healthy, happy and seems to have grown out of his reflux altogether.
Some things that we did that helped:
Feed upright. While breastfeeding, it was the football hold, but modified so he was sitting straight up. Burp often. After feeding, we would keep him upright for 20-30 minutes. Keep a book nearby for those 4 a.m. feedings!
Sleep at an angle. At first, we just put him in the car seat in his Pack n' Play to keep him from lying flat. Then we bought the wedge for his crib and that did the same thing. On really bad nights/naptimes where he just would not go down, I slept with him while sitting up. Not fun, but if you get someone to help you arrange pillows carefully, it isn't so painful for you.
Avoid anything that presses on their tummy. Loose clothing and pajamas. Tummy time is harder, but I found if I took a rolled towel and put it under his chest, he was less likely to spit up. And, if he did spit up, it's just a towel.
Buy about 3 dozen burp cloths and keep them in strategic places around the house. That way, you'll never be without one. We also used to put them underneath his head when he was sleeping so if he spit up in the night, we wouldn't have to change his sheets. And if you keep a bib on her, you won't have to change her clothes as often. My family made fun of us for doing these things, but we would only have to change his clothes 2-3 times a day at most.
Keep some moms around you who know what you're going through. There will be times where you are crying in pain right along with her. There are forums at the PAGER site (www.reflux.org) or you can e-mail me at ____@____.com, above all, keep your humor about you. There will be times when, despite all the bibs and burp cloths, she will spit up right down the front of your last clean shirt. In public. :o)
Good luck,
D.