A.; rub them with a baby wipe, youd be surprised how clean things can get with a baby wipe, their little car seat, and their seat belts get soooo dirty i tried everything, apolstery cleaner everything one day i was fed up and wiped it with a baby wipe, cleaned it, so i would think stuffed animals would come clean too, but be wary you might have to use quite a few of them, hahaha any way its worth a try, ive cleaned a few car seats with it, and their straps ive not tried it on stuffed animals though, but if all else fails a dry cleaner person should be able to tell you or help , but that gets very expensive, but in some cases its worth it, D. s mom of 3 boys, and lots of messes,