Hi Mom J,
My son was treated for growth hormone deficiency for 6 years. If your daughter is not GH deficient it's highly unlikely that you will be able to get insurance coverage for the cost of the medication, which can run upwards of $3,000 per month. Are you willing to bear that cost for the price of a couple of inches? Also, there is little evidence that administration of GH in a nondeficient child will increase adult height -- only that growth may occur more rapidly. There are other problems associated with GH administration, such as development of intracranial hypertension and potential overgrowth of heart tissue. Even though these side effects are rare, I don't think it's worth giving rGH if your daughter makes enough on her own. Besides, you should know that this needs to be injected into your daughter's leg or abdomen every night -- not a pleasant undertaking!
What you SHOULD look into, however, is if your daughter is producing adequate IGF 1 and IGFBP 3. If she makes plenty of GH, but does not make sufficient carrier protein (IGF 1) or binding protein (IGFBP 3), her body cannot use the GH it produces effectively. Supplementation of these proteins is now available and is used to treat people with certain types of carrier protein and receptor growth disorders such as Yaron syndrome.
Other things to consider (I hope the doc has done this already!) are kidney and gastrointestinal disorders that can affect nutrient absorption, causing reduced growth and/or failure to thrive. Interestingly, growth slow down can be the first symptom of Crohn's disease, and can manifest 2 - 3 years before other symptoms, such as gastric pain and diarrhea, arise. Unfortunately, it is difficult to make this association until after Crohn's is diagnosed, and it is not well recognized. This was the case with my son. He stopped growing at about age 9, we recognized the stoppage as more than a slow down by age 10, and he was diagnosed with idiopathic GH deficiency at 11. Although he showed the first signs of Crohn's at age 13, the symptoms were not recognized as such. Apparently, the growth hormone he was taking was actually somewhat protective until he finished therapy at age 17, and he was not diagnosed with active Crohn's until 2 years ago at age 19. We did not learn of the association with GH deficiency until I came across the work of an eminent metabolic specialist, Dr. Alfred Slonim, at Columbia University (in NY) by accident earlier this year. He made the connection over a decade ago when he recognized a pattern in many of his pediatric GH deficiency patients.
This is not to say that your daughter has Crohn's disease! This is only to serve as an example of other things that can cause poor/slow growth. You should check out the Magic Foundation website for other information and ideas: http://www.magicfoundation.org.
BTW, my son, who was projected to reach 5'2" before administration of GH, is now 5'10". The shots definitely worked. Not only did he begin growing within a matter of weeks, but his energy levels increased and his body fat decreased. Thanks to an innovative Crohn's diet prescribed this past June by Dr. Slonim (our angel!), he is also healthy and functioning for the first time in 3 years.
One more BTW, and a good reason to be careful about misinformation passed by moms who may or may not have medical/scientific background on this site. Growth hormone used today is not derived from animals or humans, as was the case 30 years ago. It is manufactured using recombinant technology. It comes as lyophilized (super dried) pure protein with no preservatives of any kind. Before it can be injected, it has to be reconstituted with sterile saline (salt water). Again, no preservatives, mercury, etc.
As for contracting diseases from monkeys via immunization with varicela zoster vaccine, there is no documented SCIENTIFIC evidence that this has occurred. In the 1960's, it was discovered that a simian (monkey) virus, SV40, was detected in cancer patients who had received polio vaccine manufactured using a cell culture derived from monkey kidney cells. Since then, great care has been taken in vaccine production to use cell lines that do not harbor this virus. Even so, since then, SV40 has been found in cancer patients who were never immunized with infected polio vaccine, and current hypothesis now is that this virus, which is very difficult to differentiate from similar human viruses, is not transmitted via vaccines, but has entered the human population and is transmitted through another route. Use of simian DNA in recombinant molecular biology has nothing to do with disease transmission, either. There is actually very little difference in the sequence of human and monkey DNA (only about 3% of the genome is different), and most of these differences occur in genes controlling protein manufacture and animal development. The proteins they produce are mostly identical to human proteins in both structure and function.