D.B.
We've been to the Darby Field Inn in NH many times over 25 years - just a lovely spot. Rooms in various sizes/price ranges, fantastic dining area with a view of the mountains, large country breakfast is included, pleasant grounds for hiking or lounging if the weather is good, charming tavern within the building with an adorable but well stocked bar and several nice tables (you can eat dinner/lunch there if you want), big living room with stone fireplace, hospitable hosts (husband & wife) with well trained staff, great wine list (and lots of help ordering if you want it), relaxed atmosphere and no pressure. You just make yourselves at home, and if you want help, you ask for it, but no one's in your face trying to get you to buy services like a lot of large hotels. A lot of antiques in the rooms, but many modern upgrades. It's a large old house with a few creaky floors - charming in that old New England way. It's at the end of an isolated road so there is no traffic and nothing commercial next door - just woods and private homes. There are no little kids - it's a very adult retreat.
They have some optional add-ons that I think you have to arrange ahead of time, like massages. But you aren't paying for someone to be on staff all the time if you aren't interested.
Nearby there are easy hiking trails in state reserves (look along the Kancamagus Highway which has lots of overlooks, places to stand on stones while the river goes by next to you, etc.), covered bridges, antique shops, near the North Conway shopping outlets, near downhill and XC skiing if you like that and go in the winter (but in mild weather you can take the chair lift up the mountain for a scenic view), lots of restaurants for great food (and the staff helps you - no pressure to eat dinner there), and plenty of other suggestions.
And no, I'm not related to them at all and I don't know anyone who works there! It's just a lovely gem.
You can call and ask for adjacent rooms and maybe some sort of group deal. I've seen them on Groupon and they're part of that network of some Inns that give reciprocal discounts.
Other good places are Rockport/Marblehead, Cape Cod (you might be able to rent a house off season for just a weekend rather than the full week minimum in season - we stayed at a great 5 bedroom home in Harwich with a very nice owner and a beautiful place although it might be a little big for just 5 women, though you could have your own rooms), Lenox & North Adams in Western Mass. (Rockwell museum, other art museums), Newport (expensive restaurants but maybe you can get a deal, do a mansion tour or two, great seafood, walk the Cliff Walk).
Tarrytown NY - Washington Irving house/Sleepy Hollow, some mansions you can tour, views of the Hudson River, charming town.
I realize these are all driving distance, not a flight.
Basin Harbor Club in Vergennes VT is terrific in the good weather - not sure when they open for the spring. Main house, many cottages in different sizes, right on Lake Champlain but with a small harbor, maritime museum, family owned/operated. Big porches with Adirondack chairs, lake cruises in good weather, beautiful and extensive grounds, good golf course, big dining room. Not cheap but really great. http://basinharbor.com Also family owned/operated, been there a long time. My family started going when I was a kid - everyone could do what they wanted on one large property.
Good luck and have fun!